Holmes e Watson
Sherlock Holmes (Will Ferrell) e seu fiel parceiro Watson (John C.Reilly) precisam impedir o maior dos planos malignos de Moriarty (Ralph Fiennes): assassinar a rainha da Inglaterra.
Will Ferrell
Sherlock Holmes
John C. Reilly
Dr. John Watson
Rebecca Hall
Dr. Grace Hart
Rob Brydon
Inspector Lestrade
Kelly Macdonald
Mrs. Martha Hudson
Lauren Lapkus
Millie
Pam Ferris
Queen Victoria
Ralph Fiennes
Prof. James Moriarty
Adam Scherr
Brawn
Kieran O'Brien
PC Smalls
Noah Jupe
Doxy
Bella Ramsey
Flotsam
Colby Mulgrew
Haybag
Scarlet Grace
Pickle
Billy Jenkins
Mud Fog
Michael Culkin
The Judge
Wolf Roth
Sigmund Freud
Jana Pérez
Lestrade's Wife
Nathan Osgood
Mark Twain
David Shackleton
Albert Einstein
Paul Cassidy
Charlie Chaplin
Bronson Webb
Jonathan Nightingale
Jamie-Rose Monk
Mrs. Nightingale
Jason Thorpe
Butler
Robert Cawsey
Waiter
Stanley Eldridge
Waiter
Oliver Maltman
Telegraph Operator
David Stoller
Hudson's Guard
Jack Riley
Newschild
Lilly Aspell
Newschild
