Para Maiores
Um adolescente de 15 anos tenta a todo custo encontrar um filme proibido, chamado "Movie 43". Para tanto ele conta com a ajuda de seu irmão caçula, um gênio da informática apesar de ter apenas 11 anos. Logo eles descobrem que Movie 43 é na verdade a composição de 14 curta-metragens, sendo que alguns deles são paródias dos super-heróis mais famosos da atualidade, como Super-Homem, Batman e Mulher-Maravilha.
Emma Stone
Veronica (segment "Veronica")
Hugh Jackman
Davis (segment "The Catch")
Katie Finneran
Angie (segment "The Catch")
Kate Winslet
Beth (segment "The Catch")
Johnny Knoxville
Pete (segment "Happy Birthday")
Anna Faris
Vanessa (segment "The Proposition")
Halle Berry
Emily (segment "Truth or Dare")
Chris Pratt
Jason (segment "The Proposition")
Richard Gere
Robert (segment "iBabe")
Stephen Merchant
Donald (segment "Truth or Dare")
Gerard Butler
Leprechaun 1 & 2 (segment "Happy Birthday")
Seann William Scott
Pete (segment "Happy Birthday")
Uma Thurman
Fake Lois Lane (segment "Super Hero Speed Dating")
Seth MacFarlane
MacFarlane (scene from Groening's)
Elizabeth Banks
Amy (segment "Beezel")
Naomi Watts
Samantha (segment "Homeschooled")
Kristen Bell
Fake Supergirl (segment "Super Hero Speed Dating")
Dennis Quaid
Charlie Wessler (segment "The Pitch")
Greg Kinnear
Griffin Schraeder (segment "The Pitch")
Odessa Rae
Danita (segment "The Pitch")
Common
Bob Mone (segment "The Pitch")
Charlie Saxton
Jay (segment "The Pitch")
Will Sasso
Jerry (segment "The Pitch")
Mike Meldman
Mike Meldman (segment "The Pitch")
Julie Claire
Pamela (segment "The Catch")
Roy Jenkins
Ray (segment "The Catch")
Rocky Madigan
Waiter Jake (segment "The Catch")
Anna Madigan
Abby (segment "The Catch")
Jeremy Allen White
Kevin (segment "Homeschooled")
Liev Schreiber
Robert (segment "Homeschooled")